Osaka Gas and MHI to Implement the CO2NNEX Digital Platform for Managing and Transferring the Environmental Value of e-Methane at Expo 2025 Osaka, Kansai, Japan JCN Newswire

Osaka Gas and MHI to Implement the CO2NNEX Digital Platform for Managing and Transferring the Environmental Value of e-Methane at Expo 2025 Osaka, Kansai, Japan

TOKYO, Sept 25, 2024 - (JCN Newswire via SeaPRwire.com) - Osaka Gas Co., Ltd. (Osaka Gas) and Mitsubishi Heavy Industries, Ltd. (MHI) today announced their agreement to implement CO2NNEX®, the city gas industry's first digital platform for visualizing traded carbon dioxide (CO2) at Expo 2025 Osaka, Kansai, Japan (the Expo). In addition to using this platform for e-methane, Osaka Gas and MHI will also pursue the possibility of expanding its application to carbon recycles fuel (e-fuel, SAF, Green LPG) in the future.On April 1, 2024, the private sector began to use clean gas certificates, which certifies the environmental value(Note1) of e-methane and biogas. As the same operation as non-fossil fuel certificates for electricity is proceeding for gas, a system is required to manage transactions and transfers of the environmental value of clean gas certificates. CO2NNEX® will be equipped with functions to manage e-methane attribute data (production volume, amount of CO2 and H2 used as raw materials, etc.), which is necessary for the social implementation of e-methane, and functions to manage and transfer the environmental value created by e-methane and biogas. The Japan Gas Association has indicated that further guidance will be provided to companies regarding the functions installed in this platform and proceed with implementation. (Figure 1)Figure 1: e-methane-related functions of CO2NNEXDuring the Expo, Osaka Gas will provide the guesthouses and other facilities with on-site-produced e-methane, natural gas adds a value of environmental value of e-methane or biogas. The platform will manage attributed data and the environmental value created during the production and use demonstration(Note2) of e-methane at the Expo site, as well as to transfer the environmental value of e-methane and biogas produced by city gas companies around Japan to Osaka Gas natural gas supplied to the Expo site, further contributing to the carbon neutrality of the Expo 2025. (Figure 2)Figure 2: Image of CO2NNEX implementation at the ExpoOsaka Gas aims to introduce e-methane, which accounts for 1% of the city gas it delivers, by 2030. As the value of e-methane and environmental value transactions will increase significantly in the future, MHI anticipates expanding the use of this platform, which can manage e-methane attribute data and manage and transfer environmental value. Introduction to the carbon recycling fuels other than e-methane (e-fuel, SAF, and Green LPG) is also under consideration, and as value of trade increase, a system for managing attribute data and managing and transferring environmental value is expected to become necessary. In addition to CCU(Note3) (CO2 utilization), such as carbon recycling fuel, CCS(Note4) (storage of CO2) is expected to be more widely used in the future and MHI is actively exploring the potential of expanding the application of the platform to manage CO2 distribution. Furthermore, it is also expected to expand to introduce this platform to Asian countries that are considering the introduction of e-methane and SAF. (Figure 3)Figure 3: Future potential expansion of the CO2NNEX platformThrough the development and commercialization of CO2NNEX®, Osaka Gas and MHI aim to promote the widespread usage of e-methane, contributing to achieving a carbon-neutral society.(1) This environmental value refers to the net zero emissions of CO2 from utilizing (combusting) e-methane, which is achieved through the carbon recycling by producing e-methane from captured CO2 emitted into or already existing in the atmosphere.(2) This e-methane production and utilization refers to the project of hydrogen supply chain development and demonstration in urban areas using e-methane produced from green hydrogen and biogas derived from kitchen waste. The project has been adopted as the FY2022 model development and demonstration project for the cost reduction in hydrogen supply utilizing the existing infrastructure.(3) CCU refers to Carbon dioxide Capture and Utilization.(4) CCS refers to Carbon dioxide Capture and Storage.About Osaka GasOsaka Gas aims to achieve net-zero emissions across its group under the Carbon Neutral Vision the company announced in 2021. Osaka Gas is developing technologies and services that drive the decarbonization of society. As a company serving customers for their life and business advancement, Osaka Gas is actively addressing climate change and other social challenges.About MHIMHI Group is actively involved in programs targeting the realization of a carbon neutral society. Building a CO2 ecosystem is central to its energy transition initiatives. As a global leader in CCUS, the company aims to accelerate this ecosystem development by seeking widespread adoption of related hardware as well as the CO2NNEX® digital platform.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com. Copyright 2024 JCN Newswire via SeaPRwire.com.
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Hitachi Rail Unveils the ‘HMAX’ AI Solution, Accelerated by NVIDIA, to Optimize Trains, Signaling and Infrastructure JCN Newswire

Hitachi Rail Unveils the ‘HMAX’ AI Solution, Accelerated by NVIDIA, to Optimize Trains, Signaling and Infrastructure

LONDON, Sept 25, 2024 - (JCN Newswire via SeaPRwire.com) - Hitachi Rail’s digital asset management suite – powered by NVIDIA AI technology – launches today and is transforming the way transport operators run and maintain railways.The HMAX (Hyper Mobility Asset Expert) suite is an all-in-one digital asset management platform that providestransport operators with an array of AI-enhanced digital solutions to optimize trains, signaling and infrastructure management.Hitachi’s digital tools already use digital sensors to remotely monitor the health of assets and improve their performance. The HMAX platform offers a leap forward as live data collection is combined with powerful AI technologyto dramatically enhance the speed, ease and depth of analysis. Using the powerful insights offered by HMAX, operators can now more accurately predict, optimize and transform their services.Hitachi Rail is leveraging NVIDIA’s industrial AI platform and software tools, and Hitachi Digital’s AI Centre ofExcellence and software engineering expertise, to offer operators more advanced, innovative solutions. The HMAX digital platform’s “edge to cloud” architecture means Hitachi Rail’s customers will be able to remotely access theseinnovations all through a single portal, as well as at operational centers. The solutions are part of Hitachi’s vision to bring the power of AI into the world of Operational Technology, equipping frontline workers, engineers and operators with the powerful benefits of AI.The collaboration with NVIDIA incorporates the industrial-grade NVIDIA IGX platform with NVIDIA Holoscan sensor processing platform, allowing volumes of data to be processed at the ‘edge’ (on the trains or infrastructure) in real time, with only relevant information sent back to the operational control centers. This enables an unprecedented improvement in the speed that actionable insights reach transport operators, as previously it could take up to ten days for data to be processed in maintenance locations.Speaking at the company’s showcase at InnoTrans, Berlin, Hitachi Rail CEO, Giuseppe Marino, said:“At Hitachi Rail, we believe AI has immediate and very impactful applications that will make the railways run more efficiently. Our AI-enabled digital asset management is a solution for optimizing customers’ rail services and enhancing railway performance. We are delighted by our collaboration with NVIDIA, which will combine the power ofAI with advanced Hitachi Rail technologies to enhance railway outcomes for operators.”Yogesh Agrawal, Vice President of Data Center Business at NVIDIA, said:“The railway, a system strengthened by the first industrial revolution, is at the forefront of the latest paradigm shift toward a digital transformation with AI. Hitachi Rail’s HMAX solution, powered by NVIDIA IGX and Holoscan, will offerthe real-time computing capabilities needed to help boost the manageability, safety and availability of rail systems to meet the needs of operators and today’s travelers.”About NVIDIA IGXNVIDIA IGX is an edge AI platform that combines enterprise-level hardware, software and support. It is purpose-built for industrial and medical environments, delivering powerful AI compute, high-bandwidth sensor processing, enterprise security and functional safety.The Hitachi Digital AI Center of Excellence (COE) serves as a hub for Hitachi and its customers – providing a common AI infrastructure, governance, and technical and operational expertise. The COE’s knowledge and resourceswill be augmented by the NVIDIA collaboration.About Hitachi RailHitachi Rail is committed to driving the sustainable mobility transition and has a clear focus on partnering with customers to rethink mobility. Its mission is to help every passenger, customer and community enjoy the benefits of more connected, seamless and sustainable transport.With revenues of over €7bn and 24,000 employees across more than 50 countries, Hitachi Rail is a trusted partnerto the world’s best transport organisations. The company's reach is global, but the business is local - with successbuilt on developing local talent and investing in people and communities.Its international capabilities and expertise span every part of the urban, mainline and freight rail ecosystems – fromhigh quality manufacturing and maintenance of rolling stock to secure digital signaling, smart operations and payment systems. Copyright 2024 JCN Newswire via SeaPRwire.com.
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Global Advanced Metals Partners With Department of Defense to Re-Establish Niobium Oxide Production Capabilities ACN Newswire

Global Advanced Metals Partners With Department of Defense to Re-Establish Niobium Oxide Production Capabilities

BOYERTOWN, Pa., Sept 25, 2024 - (ACN Newswire via SeaPRwire.com) - Global Advanced Metals (GAM), a leading global producer of metallurgical products, is pleased to announce a new partnership with the U.S. Department of Defense (DOD) to re-establish defense-critical niobium oxide production. The project, supported by a $26.4 million award from the Manufacturing Capability Expansion and Investment Prioritization directorate, leverages GAM's existing tantalum production in Boyertown, Pennsylvania.GAM LogoThe DOD's capital contribution will accelerate the development of the United States' first niobium oxide production in over 30 years. Niobium oxide is a precursor to high-purity superalloys in advanced aircraft, rocket systems, and various other defense platforms. GAM's public-private partnership forms a key component of the DOD's ongoing efforts to solidify the U.S. aerospace and defense industrial base."GAM is proud to contribute to strengthening U.S. and allied capability by mitigating supply vulnerabilities previously exploitable by our adversaries," said GAM's CEO, Andrew O'Donovan. "Every opportunity to decrease adversarial influence over defense supply chains should be taken, and we are delighted that the DOD chose to support GAM in this endeavor.""Pennsylvania has built and powered our Nation for generations, so it's no surprise that workers in Berks County will soon produce critical minerals to make the aircraft, rocket systems, and other equipment our military needs to ensure our national security," said U.S. Senator Bob Casey (D-PA). "I advocated for our Commonwealth to tackle this critical mineral risk so that we can continue the proud tradition of supporting our warfighters and the Department of Defense as a whole.""As a former chemistry teacher and Air Force officer, I've been championing efforts on critical mineral supply chains and the importance of bringing related manufacturing back to the U.S. since I first arrived in Congress," said U.S. Congresswoman Chrissy Houlahan (D-PA). "So when I visited Global Advanced Metals (GAM) in Berks County last year, I was in awe of their state-of-the-art operations - I knew GAM and companies like them have the blueprint we need to reduce reliance on countries like China for critical minerals. I'm so thrilled to hear GAM is receiving a $26.4 million award for niobium processing and manufacturing of defense-critical materials! With this federal investment, more jobs in our community will be created and our national security will be strengthened."About GAMA leading conflict-free tantalum producer, GAM has exclusive rights to the world's largest industrial resources of tantalum ore located in Western Australia.GAM produces conflict-free tantalum powders and metallurgical products at its Pennsylvania, USA and Aizu, Japan plants for a range of industries including electronics, aerospace, automotive, medical and chemical processing.GAM's smelting facilities in Japan and the USA were first declared "Conflict-Free" in 2010 under the former EICC/GeSI Conflict-Free Sourcing Initiative (CFSI) audit program and continue to maintain their conformance to the current Responsible Minerals Assurance Process (RMAP) standard.Contact InformationKurt HabeckerSr. Marketing Managerkhabecker@globaladvancedmetals.com1 610-369-8220SOURCE: Global Advanced Metals Copyright 2024 ACN Newswire via SeaPRwire.com.
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Ayam Australia yang disayangi dengan nama terkenal dibuang ke kandang buaya, mengejutkan pengunjung taman hidupan liar: laporan berita

Ayam Australia yang disayangi dengan nama terkenal dibuang ke kandang buaya, mengejutkan pengunjung taman hidupan liar: laporan

(SeaPRwire) - Seorang lelaki mengaku bersalah atas satu tuduhan serius selepas membuang ayam kesayangan dan dihormati bernama "Betty White" dari taman hidupan liar, ke dalam kandang aligator, semata-mata untuk memberi makan reptilia tersebut, menurut laporan.Nine News di New South Wales melaporkan bahawa Peter Smith, 58 tahun dari Hunterview mengaku bersalah di Mahkamah Raymond Terrace atas satu tuduhan kekejaman haiwan yang diperburuk, yang membawa hukuman maksimum penjara dua tahun dan denda hampir $25,000.Peguam Smith, Bryan Wrench, berkata di mahkamah bahawa kes itu adalah "perkara yang sangat luar biasa," sambil menambah bahawa anak guamnya hanya ingin memberi makan ayam kepada aligator yang lapar di Oakvale Farm and Fauna World di Salt Ash, di New South Wales.Wrench memberitahu bahawa terdapat peribahasa lama, "jangan pernah tersenyum pada buaya," tetapi dalam kes ini, aligator itu gembira selepas memakan Betty White.Rekod jenayah Smith adalah tidak wujud, kata Wrench, sambil menambah anak guamnya adalah seorang datuk, membesar di negara dan "hanya ingin memberi makan aligator."Perry dilaporkan memberitahu Wrench bahawa dia tidak pasti sama ada mempermudah keadaan itu adalah sesuai, sambil berkata, "Ini adalah tuduhan yang serius."Majistret kemudian berkata kekejaman haiwan yang diperburuk di New South Wales membawa hukuman maksimum penjara dua tahun dan denda $24,084.Dengan penalti yang begitu berat, Perry menegaskan kepada peguam bahawa ini adalah "bukan sesuatu yang boleh dibuat-buat, kemudian."Wrench memberitahu majistret 750 juta setiap tahun, menjelaskan bahawa dia tidak mempermudah keadaan itu.Selepas mengaku bersalah, hakim menangguhkan kes itu sehingga 20 November, apabila Smith akan dijatuhi hukuman.Menurut dokumen mahkamah yang diperoleh oleh Nine News, polis mendakwa Smith melakukan tindakan kekejaman haiwan yang diperburuk pada "sekor ayam bantam silkie," iaitu satu baka ayam.Tindakan itu berlaku antara 2:57 dan 3:10 petang pada 2 Januari di Oakvale Farm and Fauna World.Polis bertindak balas terhadap laporan bahawa ayam yang dikenali sebagai "Betty White" telah diambil dari kandang dan dibuang ke dalam kandang aligator, mengejutkan keluarga yang menyaksikan pemakanan yang tidak dirancang itu.Digital telah menghubungi Oakvale Farm untuk mendapatkan komen.Pemilik Oakvale Farm, Kent Sansom, mengeluarkan kenyataan selepas ayam betina itu dibunuh, dengan mengatakan kakitangan dan pengurusan "sangat sedih" dengan kematian Betty White."Ini adalah kali pertama dalam 43 tahun kami mengalami seorang ahli awam (didakwa) melakukan kekejaman seperti itu di tempat yang merupakan tempat perlindungan haiwan," kata Sansom dalam kenyataan yang diperoleh oleh stesen itu. "Betty White dibesarkan dengan tangan di taman dan memainkan peranan penting dalam program pembiakan spesies terancam kami untuk burung batu padang pasir dan spesies lain dengan menyediakan pengganti kepada anak ayam."Sifatnya yang tenang bermakna dia tidak akan teragak-agak untuk menghampiri pelanggan untuk mendapatkan beberapa pelet haiwan, menjadikannya sasaran mudah bagi (didakwa) pelaku yang kejam," tambah Sansom.Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Sandvik AB – Jawatankuasa Pencalonan untuk Mesyuarat Agung Tahunan 2025 kewangan

Sandvik AB – Jawatankuasa Pencalonan untuk Mesyuarat Agung Tahunan 2025

(SeaPRwire) - STOCKHOLM, Sept. 24, 2024 — Pada tahun 2020, Mesyuarat Agung Tahunan Sandvik AB telah mengadopsi arahan mengenai pelantikan Jawatankuasa Pencalonan, yang terpakai sehingga Mesyuarat Agung memutuskan sebaliknya. Berdasarkan arahan ini, syarikat hendaklah mempunyai Jawatankuasa Pencalonan yang terdiri daripada ahli yang dilantik oleh setiap empat pemegang saham utama dalam hal bilangan undi pada hari bekerja terakhir bulan Ogos, serta Pengerusi Lembaga Pengarah (yang bersidang). Jawatankuasa Pencalonan kini telah dilantik dan terdiri daripada ahli-ahli berikut: Fredrik Lundberg, AB Industrivärden, Pengerusi Jawatankuasa Pencalonan Daniel Kristiansson, Alecta Marianne Nilsson, Swedbank Robur Funds Lars Pettersson, Lundbergs Johan Molin, Pengerusi Lembaga Pengarah Sandvik Jawatankuasa Pencalonan hendaklah menyediakan cadangan untuk Mesyuarat Agung Tahunan 2025 mengenai Pengerusi Mesyuarat, bilangan ahli Lembaga Pengarah, yuran yang hendak dibayar kepada setiap ahli Lembaga Pengarah, pemilihan ahli Lembaga Pengarah dan Pengerusi Lembaga Pengarah, pampasan kepada juruaudit dan pemilihan juruaudit dan, jika perlu, cadangan untuk perubahan dalam arahan kepada Jawatankuasa Pencalonan. Mesyuarat Agung Tahunan akan diadakan pada April 29, 2025 di Sandviken, Sweden. Pemegang saham yang ingin mengemukakan cadangan kepada Jawatankuasa Pencalonan untuk Mesyuarat Agung Tahunan 2025 boleh mengemukakannya kepada Setiausaha Jawatankuasa Pencalonan Åsa Thunman melalui e-mel: . Agar Jawatankuasa Pencalonan dapat mempertimbangkan cadangan yang dikemukakan dengan cara yang konstruktif, cadangan ini hendaklah dikemukakan selewat-lewatnya pada January 20, 2025. Untuk maklumat lanjut, sila hubungi: Louise Tjeder, VP Hubungan Pelabur, telefon: +46 (0) 70782 6374 atau Johannes Hellström, Pengurus Perhubungan Akhbar dan Media, telefon: +46 (0) 70721 1008 Sandvik Group Sandvik adalah kumpulan kejuruteraan berteknologi tinggi global yang menyediakan penyelesaian yang meningkatkan produktiviti, keuntungan dan kemampanan untuk industri pembuatan, perlombongan dan infrastruktur. Kami berada di barisan hadapan pendigitalan dan memberi tumpuan untuk mengoptimumkan proses pelanggan kami. Tawaran kami yang terkemuka di dunia termasuk peralatan, alat, perkhidmatan dan penyelesaian digital untuk pemesinan, perlombongan, penggalian batu dan pemrosesan batu. Pada tahun 2023, Kumpulan ini mempunyai kira-kira 41,000 pekerja dan hasil kira-kira SEK 127 bilion di kira-kira 170 negara. Maklumat ini telah disampaikan kepada anda oleh Cision Fail berikut boleh dimuat turun: Sandvik AB — Nomination Committee for the 2025 Annual General Meeting SOURCE SandvikArtikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Penyokong bunuh diri berbangga dengan penggunaan kapsul bunuh diri Sarco terhadap warga AS di Switzerland berita

Penyokong bunuh diri berbangga dengan penggunaan kapsul bunuh diri Sarco terhadap warga AS di Switzerland

(SeaPRwire) - Beberapa orang telah ditahan berhubung dengan penggunaan "kapsul bunuh diri" yang kelihatan sukarela.Pegawai polis kanton Schaffhausen di utara Switzerland mengumumkan pada hari Selasa bahawa beberapa orang telah ditahan berikutan petunjuk yang menunjukkan individu-individu telah dibantu untuk membunuh diri di sebuah pondok di Merishausen.Siasatan mengenai kemungkinan hasutan dan aksesori kepada bunuh diri sedang dijalankan, dan kematian yang dirancang itu boleh dikaitkan dengan penggunaan pertama kapsul bunuh diri jenama Sarco.Sarco pod adalah mesin bunuh diri yang dibangunkan oleh kumpulan pro-euthanasia yang berpangkalan di Belanda, Exit International.Kumpulan itu kelihatan bertanggungjawab atas jenayah yang didakwa dalam satu kenyataan, mengumumkan kematian seorang wanita tua yang merupakan warganegara Amerika Syarikat dan mengalami penyakit imun yang teruk."Di Switzerland pada hari Isnin, seorang wanita berusia 64 tahun meninggal dunia di dalam 'kapsul bunuh diri' yang direka khas yang mengandungi gas nitrogen. Ini adalah kali pertama kapsul bunuh diri ini, yang dipanggil Sarco, digunakan," Exit International membanggakan diri dalam siaran akhbar dalam talian. "Kapsul itu, sebuah kabin kedap udara seukuran keranda, menawarkan, menurut penciptanya, 'kematian yang cepat, aman dan boleh dipercayai' tanpa bantuan doktor atau ubat.""Masih tidak jelas bagaimana keadilan Switzerland akan bertindak balas terhadap perkara ini," kenyataan kumpulan pro-bunuh diri itu berterusan. "Syarat yang ditetapkan oleh negara adalah bahawa orang yang mempunyai keinginan mati adalah kompeten dari segi mental, bahawa mereka melakukan tindakan maut terakhir itu sendiri dan bahawa orang yang membantu mempunyai motif yang tidak mementingkan diri sendiri."Pengasas Exit International Dr. Philip Nitschke mengumumkan pada hari Selasa bahawa dia "gembira kerana Sarco telah berfungsi tepat seperti yang dirancang […] untuk menyediakan kematian pilihan, bukan dadah, yang aman pada masa yang dipilih oleh individu itu."Exit International mengatakan Nitschke secara peribadi "mengesahkan" kematian wanita Amerika Syarikat itu.Switzerland adalah negara pertama di dunia yang mengesahkan kematian dibantu, menggubal undang-undang untuk penginapan itu pada tahun 1941.Undang-undang Switzerland membenarkan pesakit untuk diberi penginapan semasa membunuh diri hanya jika mereka melakukannya tanpa "bantuan luaran" dan tidak dibantu oleh individu dengan "motif mementingkan diri sendiri."Kapsul Sarco direka untuk mengisi dirinya dengan gas Nitrogen, menyebabkan mangsa tertidur sebelum mencekik mereka dalam masa 10 minit selepas diaktifkan.Ia dicetak 3-D dan dipamerkan di Venice Design Festival pada tahun 2019.Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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NXLog Mendefinisikan Semula Pasaran dengan Pelancaran Platform NXLog: Penyelesaian Pengurusan Log Berpusat Baru dengan Paip Log Terkemuka Industri kewangan

NXLog Mendefinisikan Semula Pasaran dengan Pelancaran Platform NXLog: Penyelesaian Pengurusan Log Berpusat Baru dengan Paip Log Terkemuka Industri

(SeaPRwire) - DUBAI, Emiriah Arab Bersatu, Sept. 24, 2024 — NXLog, peneraju global dalam teknologi pengumpulan log, mengumumkan pelancaran inovasi terbarunya dalam penyelesaian pengurusan log. Produk baharu ini, yang dijangka akan mentakrif semula standard keselamatan dan integrasi data, menggabungkan ciri-ciri canggih dengan kemudahan penggunaan, yang memenuhi keperluan infrastruktur IT moden yang berkembang. Pelancaran ini menandakan satu peristiwa penting dalam komitmen NXLog untuk menyediakan alat pengurusan log yang boleh dipercayai dan berskala. NXLog Platform NXLog Platform menawarkan penyelesaian pengurusan log pusat berprestasi tinggi, yang direka khusus untuk meningkatkan keselamatan siber dan pematuhan. Ia adalah sistem pengurusan log terpusat dengan keupayaan saluran paip log yang terkemuka dalam industri, menyediakan pengumpulan log berasaskan agen dan tanpa agen yang boleh disesuaikan dengan pelbagai persekitaran IT. NXLog Platform boleh menyimpan dan menganalisis data log secara bebas atau berintegrasi dengan sistem SIEM hulu untuk meningkatkan kefungsian. Penyelesaian baharu ini bersedia untuk awan, memastikan skalabiliti untuk mengendalikan jumlah data yang besar. Selain itu, ia menampilkan enjin pangkalan data tanpa skema, volum tinggi yang mengoptimumkan penyimpanan dan pengurusan log, yang membantu mengurangkan perbelanjaan dan memastikan pematuhan dengan peraturan. Ciri-ciri yang bersedia untuk ICS/SCADA membolehkan peningkatan kebolehpercayaan operasi dan keselamatan infrastruktur terhadap ancaman moden, melindungi infrastruktur kritikal dan mencapai pematuhan dengan standard dan peraturan keselamatan siber. Integrasi pelbagai platform yang pantas memudahkan pemprosesan data "hujung ke SIEM" yang cekap. Ia mengurangkan masa dan overhead penghijrahan, menjadikannya alat yang berharga untuk organisasi yang mencari keupayaan pengurusan log yang kukuh dan serba boleh. Dalam kenyataan mengenai pelancaran itu, Botond Botyánszki, Ketua Pegawai Eksekutif dan pengasas NXLog, menekankan komitmen syarikat yang tidak berbelah bahagi kepada rakan kongsinya dalam keselamatan siber dan pematuhan. “Kami menawarkan penyelesaian pengurusan log dan agen yang mantap, bernilai tinggi dan terpusat kepada rakan kongsi sedia ada dan bakal kami yang memberi tumpuan kepada keselamatan siber dan pematuhan.” Kata Botyánszki dalam ucapannya mengenai pelancaran produk baharu itu. “NXLog Platform adalah alat yang cekap, berskala dan boleh dipercayai yang direka khas untuk keperluan pasukan keselamatan organisasi perusahaan.” About NXLog NXLog terkenal dengan kepakaran pengumpulan dan pengurusan log, menawarkan penyelesaian serba boleh merentasi pelbagai persekitaran IT. Ia mempunyai lebih daripada 12 tahun pengalaman dan 600 pelanggan di seluruh dunia, termasuk syarikat Fortune 500. Dengan tumpuan kepada kebolehpercayaan, skalabiliti, dan keselamatan, NXLog telah mewujudkan dirinya sebagai rakan kongsi yang dipercayai dalam pengumpulan dan pengurusan data log, membantu organisasi menyelaraskan dan meningkatkan usaha keselamatan siber mereka. Ketahui lebih lanjut di .Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Pemimpin Iran Akan Berucap di PBB di Tengah Ancaman Pembunuhan terhadap Ahli Politik AS, Campur Tangan Pilihan Raya

(SeaPRwire) - Presiden Iran Masoud Pezeshkian akan menyampaikan ucapan di Sidang Umum Pertubuhan Bangsa-Bangsa Bersatu Selasa petang di Bandar Raya New York di tengah-tengah banyak cerita yang melibatkan keterlibatan Tehran dalam cubaan pembunuhan terhadap ahli politik AS dan campur tangan pilihan raya.Pezeshkian, yang menarik perhatian minggu ini untuk delegasi 40 anggotanya yang dilaporkan termasuk anak-anak dewasa beliau, telah menjadi berita utama sebaik sahaja tiba untuk komen yang dibuat beliau yang mencadangkan Israel sedang mencari untuk memulakan perang total di Timur Tengah dengan menjadikan Lubnan sebagai Gaza seterusnya."Kami tidak mahu menjadi punca ketidakstabilan di Timur Tengah kerana kesannya tidak dapat dipulihkan," katanya kepada wartawan pada Isnin, menurut Reuters. "Kami mahu hidup aman, kami tidak mahu berperang."Israel yang berusaha untuk mewujudkan konflik total ini," tambah beliau.Ucapan beliau di Sidang Umum dijangka memberi tumpuan kepada perjuangan berterusan di Timur Tengah kerana Israel mendapati dirinya berhadapan dengan proksi pengganas Iran Hamas dan Hizbullah.Komen Pezeshkian mungkin akan menarik perhatian kepada di Gaza, dan baru-baru ini serangan udara Israel di Lubnan, di mana hampir 500 orang terbunuh, menurut Kementerian Kesihatan Lubnan, lapor BBC awal Selasa. Tidak diketahui berapa ramai daripada mereka yang terbunuh adalah pengganas Hizbullah.Walaupun PBB telah mengecam serangan Israel terhadap orang awam, komen presiden Iran itu mungkin kedengaran kosong di kalangan beberapa orang di badan antarabangsa itu kerana Tehran telah menyokong dengan ketara organisasi pengganas yang terlibat dalam perjuangan melawan negara Yahudi itu.Terdapat juga isu lain mengenai plot terbongkar Tehran untuk membunuh Donald Trump, serta berpotensi Presiden Biden, Nikki Haley, bersama-sama dengan "ahli politik, anggota tentera atau birokrat" yang lain, menurut dokumen FBI yang dikeluarkan oleh Senator Charles Grassley, R-Iowa, awal bulan ini.FBI selanjutnya mengesahkan minggu lalu bahawa penggodam Iran cuba membekalkan kempen presiden Demokrat dengan fail komunikasi yang dicuri dari kempen Trump.Walaupun kelihatannya percubaan Iran untuk meniru gaya Rusia yang digunakan semasa kempen 2016 adalah usaha gagal untuk menimbulkan kekacauan di AS menjelang pilihan raya, plot pembunuhan itu mungkin disebabkan oleh pembunuhan Jeneral Qasem Soleimani pada tahun 2020 semasa Trump menjadi presiden.Perjalanan Pezeshkian ke AS untuk mesyuarat utama PBB bulan lalu. Mereka menggalakkan Biden untuk menyekat visa beliau atas kebimbangan kehadiran beliau akan "menimbulkan isu keselamatan yang serius" untuk AS dan sekutunya.Penunjuk perasaan mogok lapar juga dilaporkan di penjara wanita yang terkenal di Iran sebagai protes terhadap ucapan presiden Iran di tengah-tengah peningkatan jumlah pelaksanaan di Tehran dan sebagai panggilan untuk pembebasan semua tahanan politik dan ideologi, menurut Iran International.Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Overview of Honda Exhibits at JAPAN MOBILITY SHOW BIZWEEK 2024 JCN Newswire

Overview of Honda Exhibits at JAPAN MOBILITY SHOW BIZWEEK 2024

TOKYO, Sept 24, 2024 - (JCN Newswire via SeaPRwire.com) - Honda announced that it will participate in JAPAN MOBILITY SHOW BIZWEEK 2024 to be held at Makuhari Messe in Chiba Prefecture, Japan from October 15 (Tuesday) to 18 (Friday), 2024.Honda boothJAPAN MOBILITY SHOW BIZWEEK 2024 will be held as an event to promote new business co-creation by strengthening collaboration between companies. The Honda booth aims to communicate with participating and visiting companies by showcasing UNI-ONE capable of DX coordination such as augmented reality (AR) and virtual reality (VR), and seek partners interested in selling / handling “SmaChari,” a service that converts conventional bicycles to be electrically assisted and connected by attaching an electric power assist unit and connecting a smartphone app.Honda will also introduce IGNITION, a new business creation program aimed at solving social issues, and Honda Xcelerator Ventures, an open innovation program promoting collaboration between startup companies and Honda.Main exhibitsUNI-ONE Hands-Free Personal MobilityUNI-ONE is a seated personal mobility that allows the user to use both hands freely. Through Honda’s balance control technology developed from robotics research and the unique Honda Omni Traction Drive System, UNI-ONE users can walk at a height close to pedestrians while both hands are free, enabling communication with surrounding people while moving. UNI-ONE assists the mobility of various people, and creates the joy of freedom of mobility, enhancing the user’s desire to move. By adding a DX aspect to the UNI-ONE, Honda will search for, and communicate with, partners to provide a new future mobility experience.SmaChariSmaChari consists of a smartphone application and an electric power assist unit attached to a bicycle. It is the first of its kind in Japan(1) and enables various types of bicycles to be electrically assisted and connected through output control technology that complies with regulations. In addition, using a smartphone application, users can access a variety of functions and information utilizing the connected functionality, such as personalized assist output optimization, fault detection, ride data management, location information sharing, and owner information management.Honda will provide SmaChari smartphone apps to customers, as well as various licenses to companies that manufacture and sell SmaChari-equipped bicycles, including technology related to the control software of the electric power-assist unit, and a paid connected platform to operate and manage SmaChari.Honda aims to equip SmaChari on a wide range of bicycles in the future, and will continue to evolve the system.(1) As of March 2023 (Honda research)IGNITIONIGNITION is a new business creation program started by Honda R&D Co., Ltd. in 2017, which gives shape to the creative technologies, ideas, and designs of employees, leading to the solution of social issues and the creation of new values. In 2021, the program was expanded to cover all of Honda.Since then, IGNITION expanded beyond Honda, and by combining ideas from outside the company with Honda’s technologies and expertise, the program aimed to further solve social issues and create new values. In 2024, Honda has selected three themes from applications to a public invitation, to help solve the social issues raised in the selected themes.Reference: Selected themesMobility that enables rapid standing-up and standing mobility, for people with lower limb motor function disabilities who have difficulty standing up and walking long distances (Yosuke Eguchi, Qolo Co., Ltd. CEO)Walking rehabilitation system for stroke patients that is easy to use and fun for rehabilitation (Prof. Yano, Virtual Reality Laboratory, University of Tsukuba)“Robiotope” aiming to protect nature by fostering a sense of attachment to nature and environmental awareness, through growing plants with robots in a biotope of their choice (Toki Kageyama, National Institute of Technology, Numazu National College of Technology)Honda Xcelerator VenturesHonda Xcelerator Ventures is Honda’s open innovation program that promotes collaboration between Honda and startup companies. Through this program, Honda is investing in and collaborating with a number of global venture companies with advanced technologies in Japan, North America, Europe, Israel, among other regions.In April 2023, Honda established Honda Innovations Co., Ltd. in Japan to conduct global corporate venturing, and established a system for speedy investment and collaboration with startups that possess innovative technologies and ideas in conjunction with Honda’s corporate strategy. Honda has allocated an annual budget on the scale of 10 billion yen to invest in startups and other companies with promising cutting-edge technologies and business models in areas such as AI, synthetic fuels, battery recycling, and nuclear fusion power generation, aiming to broaden the scope of its technologies and businesses in the future.Helm.ai (U.S.): AI image recognition technology based on unsupervised learningEmulsion Flow Technologies Ltd. (Japan): efficient extraction of rare metals from batteriesnT-Tao (Israel): Developing small modular fusion power generationIn addition, the Japan Automobile Manufacturers Association (JAMA) will exhibit vehicles such as the CR-V e:FCEV fuel cell vehicle and the EM1 e: electric personal commuter motorcycle.Honda Exhibits Honda boothExhibited modelsUNI-ONERAIL DISC-e with SmaChariMessageIGNITIONHonda Xcelerator VenturesJAMA’s member automobile manufacturers boothExhibited models(All production models)CR-V e:FCEVEM1 e:Honda Power Pack e:Honda Power Pack Exchanger e:JAPAN MOBILITY SHOW BIZWEEK 2024 OverviewTitleJAPAN MOBILITY SHOW BIZWEEK 2024DatesOctober 15 (Tuesday) - 18 (Friday), 2024Times10:00~17:00VenueMakuhari Messe (International Exhibition Hall 1)Address2-1 Nakase, Mihama-ku, Chiba-shi, ChibaAdmissionFree (online registration required)OrganizerJapan Automobile Manufacturers Association, Inc. (JAMA)SponsorJapan Auto Parts Industries Association (JAPIA)Websitehttps://www.japan-mobility-show.com/en/ Copyright 2024 JCN Newswire via SeaPRwire.com.
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Tosha Schareina Wins FIM E-Xplorer World Cup Men’s Category JCN Newswire

Tosha Schareina Wins FIM E-Xplorer World Cup Men’s Category

TOKYO, Sept 24, 2024 - (JCN Newswire via SeaPRwire.com) - Tosha Schareina (Spain, age 29), riding the CR ELECTRIC PROTO motocross racer for Honda Racing Corporation (HRC) factory team(1) Team HRC, was crowned champion in the men’s category in the final round of the FIM(2) E-Xplorer World Cup, an international electric all-terrain motorcycle racing series, held in Switzerland on September 21 and 22. Francesca Nocera (Italy, age 30) finished second in the women’s category, and Team HRC was second overall in the team category.HRC which announced its full participation from 2024 in the E-Xplorer World Cup, which started in 2023, has won the championship in its first year.Honda is committed to the electrification of motorcycles as the cornerstone of its environmental strategy, aiming to achieve carbon neutrality in all of its products and corporate activities by 2050 and in all of its motorcycle products by the 2040s. In the area of motorsports, the introduction of electric technology in competition has allowed Honda to accumulate know-how and knowledge, and has become a milestone in the evolution of Honda’s technology.In the 2024 season, Honda will accelerate its electrification efforts by introducing the newly developed RTL ELECTRIC in the MFJ(3) All Japan Trial Championship.Koji Watanabe, President of Honda Racing Corporation“I would like to extend my heartfelt congratulations to Tosha Schareina for winning the championship in the FIM E-Xplorer World Cup men’s category. He showed consistent and strong performance in the completely new category of electric off-road racing. I would also like to pay tribute to Francesca Nocera, who pushed hard until the end despite of pain from her fall in practice. Last but not least, I would like to thank the team staff who helped us win the championship, as well as our sponsors and all the off-road racing fans who support our racing activities.”Tosha Schareina | Team HRC“I’m absolutely thrilled to have secured the victory as the men’s World Champion in E-Xplorer. The team should be proud of all the hard work they’ve put in this season. I want to extend my congratulations to Francesca for never giving up and finishing the race after her fall on Friday. The CR ELECTRIC PROTO has performed incredibly throughout the entire year, and the team has given their all—they should be proud.”(1) Factory team: Racing team managed by the bike manufacturer. For Honda, Honda Racing Corporation (HRC) manages its factory teams.(2) FIM: Fédération Internationale de Motocyclisme(3) MFJ: Motorcycle Federation of JapanAbout Tosha SchareinaCareer highlights:2021Dakar Rally 2021: 13th2023Dakar Rally 2023: 13th2024Dakar Rally 2024E-Xplorer World Cup Champion (Men’s category)About E-XplorerThe FIM E-Xplorer World Cup is an international electric all-terrain motorcycle racing series that started in 2023, in which mixed-gender teams compete. This season’s competition consisted of qualifying and three heat races for the men’s and women’s categories to determine the top 3 teams.This year’s E-Xplorer World Cup was contested over four rounds, beginning at the Expo’70 Commemorative Park (Festival Square) in Suita City, Osaka Prefecture, on February 16-17, before moving to Norway (Round 2) and Switzerland (Rounds 3 and 4). Copyright 2024 JCN Newswire via SeaPRwire.com.
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DEXIS Digital Ecosystem Expands With Three New Innovations To Streamline and Connect Dental Workflows ACN Newswire

DEXIS Digital Ecosystem Expands With Three New Innovations To Streamline and Connect Dental Workflows

QUAKERTOWN, PA, Sept 24, 2024 - (ACN Newswire via SeaPRwire.com) - At the start of 2024, DEXIS introduced its digital ecosystem, a suite of tools and software designed to connect and streamline the implant workflow from diagnosis to delivery.Today, DEXIS announced upgrades across the ecosystem to aid clinicians in important workflow elements from visualizing progressive dental issues to designing chairside surgical guides."Our technology makes it easy to organize information and execute treatments, which is at the core of what clinicians expect from us," said DEXIS President, Robert Befidi. "We are connecting and standardizing the implant workflow while also constantly evaluating our efforts to ensure we provide deeper patient insights and flexible, intuitive solutions that reduce complexity. These three launches are a good example of our focus on continuous innovation across the ecosystem to deliver diagnostic confidence, productivity, and smart simplicity."A brand-new X-ray platform is now available, designed specifically for general practitioners looking to expand their diagnostic capabilities with 3D imaging. Developed and produced in Tuusula, Finland, the ORTHOPANTOMOGRAPH™ OP 3D™ EX captures consistently accurate images through a straightforward, easy-to-learn workflow. The unit has a wide range of field of view sizes to support multiple clinical indications, including implant placement, endodontics, periodontics, and analysis for airway and TMJ. Early adopters of the OP 3D EX have reported positive feedback:"When choosing a CBCT, the key factors for me were a large sensor, predictable acquisition, stellar image quality and intuitive software that wouldn't interrupt my workflow," says Dr. Tyler Tolbert of Smile Now Dental Group. "Once the OP 3D EX got here and we started taking some scans, I thought to myself, ‘We really made the right choice here!'"In addition to new hardware, a brand-new software release will provide advanced tools to plan and execute same-day, prosthetically driven implants.Serving as the unifying software and central hub of the ecosystem, DTX Studio™ Clinic stores and manages all patient data as well as helps clinicians execute each step of the implant process from diagnostics to delivery.The software's new functionality allows practitioners to plan an implant treatment and generate a surgical guide chairside - all in less than three minutes. Clinicians can virtually extract teeth, adjust photorealistic abutments and crowns, and create an automated surgical guide that can be sent to a lab or produced in-house for same-day delivery."We were able to implement the OP 3D EX quickly and start taking scans largely due to the included DTX Studio Clinic software," said Dr. Nicholas Varney of Varney Dental. "Once we got going, we found that so much of the work involved in prepping a 3D scan for confident diagnosis was done by the software automatically. DTX Studio Clinic has improved how we work in all aspects - communicating with patients, implant planning and even treatment team collaboration."In addition to 3D imaging enhancements, an intraoral scanning software update offers scan quality and usability improvements as well as clear visualizations of progressive dental issues over time, through a new tool called Oral Compare. Additionally, the software's new integration with SmileFy allows for the ability to simulate treatment outcomes chairside, giving patients further confidence in proposed treatment plans.To learn more about DEXIS and the latest implant workflow upgrades, visit https://www.dexis.com.About DEXISDEXIS is the global leader in dental imaging. We bring together the most trusted brands in 2D and 3D imaging, intraoral scanning solutions, and diagnostic software, in one connected and AI-powered ecosystem. Our innovative and award-winning technologies use smart simplicity to increase productivity and enhance diagnostic confidence. For more information, please visit dexis.com.About Envista Holdings CorporationEnvista is a global family of more than 30 trusted dental brands, including Nobel Biocare, Ormco, DEXIS, and Kerr, united by a shared purpose: to partner with professionals to improve lives. Envista helps its customers deliver the best possible patient care through industry-leading dental consumables, solutions, technology, and services. Its comprehensive portfolio, including dental implants and treatment options, orthodontics, and digital imaging technologies, covers a wide array of dentists' clinical needs for diagnosing, treating, and preventing dental conditions as well as improving the aesthetics of the human smile. With a foundation comprised of the proven Envista Business System (EBS) methodology, an experienced leadership team, and a strong culture grounded in continuous improvement, commitment to innovation, and deep customer focus, Envista is well equipped to meet the end-to-end needs of dental professionals worldwide. Envista is one of the largest global dental products companies, with significant market positions in some of the most attractive segments of the dental products industry. For more information, please visit www.envistaco.com.Contact InformationMaria PenalozaMedia & Content Strategy Managermaria.penaloza@issuerdirect.comSOURCE: DEXIS Copyright 2024 ACN Newswire via SeaPRwire.com.
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China Medical System: New Drug Application for Vitiligo Indication of Ruxolitinib Phosphate Cream Accepted in China ACN Newswire

China Medical System: New Drug Application for Vitiligo Indication of Ruxolitinib Phosphate Cream Accepted in China

SHENZHEN, Sept 24, 2024 - (ACN Newswire via SeaPRwire.com) - China Medical System Holdings Limited (the “Company”, together with its subsidiaries, the “Group” or “CMS”) is pleased to announce that on September 24, 2024, the New Drug Application (NDA) for vitiligo indication of ruxolitinib phosphate cream (the “ruxolitinib cream” or the “Product”) has been accepted by the National Medical Products Administration of China (NMPA). This is another substantial milestone for ruxolitinib cream in China, following the approval for Urgent Clinical Import by Hainan Medical Products Administration and approval for marketing in Macau for vitiligo, and it is also a key step in benefiting over ten million of patients with vitiligo in China.Ruxolitinib cream achieved positive results in Chinese Real-World Study. The primary efficacy endpoint was the proportion of patients in the treatment group who achieved F-VASI 75 response at week 24, which was 49.5%, significantly higher than the target value of 14.1% (p
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HKTDC Export Confidence Index 3Q24: Positive exporter confidence amid solid sales ACN Newswire

HKTDC Export Confidence Index 3Q24: Positive exporter confidence amid solid sales

HONG KONG, Sept 24, 2024 - (ACN Newswire via SeaPRwire.com) – Hong Kong traders remain optimistic about their prospects with a sustained period of moderate growth believed to be underway. This was the key finding of the Hong Kong Trade Development Council (HKTDC) Export Confidence Index for the third quarter of 2024 as released today.The Index – a quarterly review of the views and expectations of Hong Kong-based traders across a broad cross-section of industry sectors – showed that, despite a slight decline compared to the second quarter, underlying sentiment remains broadly positive. In another welcome outcome, the majority of the sub-indices remained in expansionary territory, a clear indication of widespread anticipation of continued growth.Putting the overall findings into context, Irina Fan, Director of HKTDC Research, said: “Hong Kong exporters remain resilient, despite the uncertainty stemming from lingering trade tensions. Indeed, the majority of respondents reported no – or only minimal – impact from the recent round of trade restrictions and higher tariffs.”Strong sales and new ordersLooking at the findings in greater detail, the overall Current Performance Index rose by 1 point to 52.6, a development seen as reflecting strong sales and new orders, rising unit prices and expanding procurement activities. This was underlined by concurrent rises in the relevant Sub-Indices – the Trade Value Sub-Index (56.2, +2.5) and Procurement Sub-Index (57.3, +3.3). Although the Sales & New Orders Sub-Index recorded a moderate 1.8-point drop, it stayed resolutely in expansionary territory at 55.7.The Expectation Index also remained in expansionary territory at 51.4 even after a 2.9-point dip. This decrease was driven mainly by the 8.5-point decline in the Trade Value Expectation Sub-Index (down to 51.7), with traders expecting unit prices to increase only moderately.The same traders, however, remained optimistic about the outlook for sales and new orders (with a Sales & New Orders Expectation Sub-Index reading of 54.6); and look set to continue to expand their procurement activities (Procurement Expectation Sub-Index: 55.4).Overall, the findings suggest that the immediate future will be characterised by moderate, sustained export growth.Cost pressures lessen, but remain major concernIt was also apparent that costs remained the major drag on exporter confidence in the third quarter. While both the Current and Expectation Cost Sub-Index showed some improvement, scores remained at about the 35 level, an indication that exporters are still facing strong cost pressures.In terms of Current Performance, exporters have seen increased Sales and New Orders across all their key markets. With regard to outlook (Expectation), exporters were most upbeat about the ASEAN bloc (59.7) and mainland China (58.4).By industry, the third quarter saw an improvement in Current Performance across all sectors. In terms of prospects for the near-term, Clothing exporters are the most optimistic at 61.2, followed by Toys (58.7) and Jewellery (56.4).Looking to the immediate future, Nicholas Fu, Senior Economist with HKTDC Research, said: “Exporters from five out of the six key sectors expect the current positive business momentum to continue. Overall, Clothing exporters were the most upbeat, followed by those in the Toys and Jewellery sectors. While it is noteworthy that cost pressures are expected to stay high across all sectors, there is some possibility of a slight improvement further down the line.”In addition to addressing the standard index criteria, the latest survey also focused on several specific thematic questions with regard to the primary challenges facing exporters and the favoured forward strategies of participants. Responses here showed that:- High and rising costs (transport, labour, production and capital) were seen as the most significant challenges.- In order to mitigate any related risks, Hong Kong exporters intend to adopt more cautionary business strategies.- Regarding the impact of recent trade restrictions and higher tariffs on certain China-origin exports, 60% of respondents reported no impact on their business to date, while 39% expect only a moderate downside.- On the sustainability front, however, fewer than 20% of respondents were familiar with the EU's newly enacted Ecodesign for Sustainable Products Regulations (ESPR), which is expected to have a broad impact across many industry sectors.Notes for EditorsThe HKTDC Export Confidence Index was introduced in the first quarter of 2024. It is a composite of five sub-indices – Sales and New Orders, Trade Value, Cost, Procurement and Inventory – and seeks to provide a comprehensive overview of Hong Kong exporter sentiment.There are two primary / overall indices, one of which gauges the Current Performance in the present quarter, while the other considers the Expectation for the upcoming quarter via a weighted average of the following five sub-indices:- Sales and New Orders: This is an indication of overall export performance as well as the level of new export orders received by respondents. This index is compiled based on respondents' feedback regarding the prospects of each of their major export markets.- Trade Value: This focuses on tracking the movement of unit export prices.- Cost: This tracks cost pressures as they relate to day-to-day operations, including raw material prices / labour and other operational costs/ financing requirements. Compared with the other indices, it is an inverted index, with an index reading above 50 indicating a downward trend for costs, while a reading below 50 indicates an upward trend for costs.- Procurement: This is a measure of the input-buying activity of Hong Kong traders.- Inventory: This tracks the overall inventory levels held by respondents for present use and the upcoming quarter. An index reading above 50 indicates a lower-than-normal inventory level, while a reading below 50 indicates a higher-than-normal inventory level.To view this press release in Chinese, please visit http://mediaroom.hktdc.com/tcReferences- HKTDC Research website: http://research.hktdc.com/- HKTDC Export Confidence Index 3Q24: Sustained Optimism Underpinned by Strong Sales and New Orders https://research.hktdc.com/en/article/MTgwNDk1NTM5OQPhoto download: https://bit.ly/4deCzLZHKTDC Director of Research Irina Fan (left) and Senior Economist Nicholas Fu (right) announced the HKTDC Export Confidence Index for the third quarter of 2024 at a press conference todayHKTDC Director of Research Irina FanHKTDC Senior Economist Nicholas FuMedia enquiriesPlease contact the HKTDC’s Communication and Public Affairs Department:Jane CheungTel: (852) 2584 4137Email: jane.mh.cheung@hktdc.orgAbout HKTDCThe Hong Kong Trade Development Council (HKTDC) is a statutory body established in 1966 to promote, assist and develop Hong Kong's trade. With 50 offices globally, including 13 in Mainland China, the HKTDC promotes Hong Kong as a two-way global investment and business hub. The HKTDC organises international exhibitions, conferences and business missions to create business opportunities for companies, particularly small and medium-sized enterprises (SMEs), in the mainland and international markets. The HKTDC also provides up-to-date market insights and product information via research reports and digital news channels. For more information, please visit: www.hktdc.com/aboutus. Copyright 2024 ACN Newswire via SeaPRwire.com.
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Zelenskyy memberi amaran pelan Vance untuk menyerahkan tanah yang dirampas Rusia akan membawa kepada ‘pertembungan global’ berita

Zelenskyy memberi amaran pelan Vance untuk menyerahkan tanah yang dirampas Rusia akan membawa kepada ‘pertembungan global’

(SeaPRwire) - Dalam temu bual pada hujung minggu dengan The New Yorker, Zelenskyy menyuarakan beberapa kritikan terkasarnya terhadap mana-mana pegawai AS sejak perang Rusia bermula ketika ditekan mengenai calon naib presiden Republikan Senator JD Vance.Zelenskyy secara jelas telah mematuhi garis apabila tiba masanya untuk pilihan raya presiden AS 2024 yang penuh kontroversi dan telah bercakap dengan setiap Presiden Biden, calon presiden Demokrat Naib Presiden Harris dan calon GOP bekas Presiden Trump.Tetapi sarung tangan ditanggalkan pada hari Ahad dalam satu temu bual di mana Zelenskyy memanggil Vance "radikal" dan memberi amaran bahawa cadangannya untuk menamatkan perang di Ukraine sebaliknya akan mendorong "pertembungan global."Vance berkata pada bulan ini bahawa jika terpilih sebagai Presiden, Trump akan bekerjasama dengan Rusia, Ukraine dan pemimpin Eropah untuk membuat perjanjian yang akan memberi Moscow wilayah yang telah dirampasnya secara haram sejak pencerobohan 2022.Setelah persetujuan Kyiv untuk memberikan tanah itu kepada Rusia, maka akan ada penciptaan zon demiliterisasi di sepanjang garis hadapan semasa, Ukraine akan diperkukuh untuk menghalang pencerobohan Rusia yang ketiga, dan Kyiv akan bersetuju untuk melupakan rancangannya untuk menyertai NATO - satu cadangan yang telah dikatakan oleh pakar keselamatan Barat akan menjadi kekalahan besar."Jika ini adalah pelan, maka Amerika menuju ke arah konflik global," kata Zelenskyy. "Ia akan bermakna bahawa sesiapa sahaja yang mendakwa memiliki wilayah - bukan pemilik yang sah tetapi sesiapa sahaja yang datang sebulan atau seminggu yang lalu dengan pistol di tangan - adalah orang yang bertanggungjawab."Presiden Ukraine memberi amaran bahawa sikap ini bukan sahaja akan merugikan Kyiv dan rakyat Ukraine, tetapi juga akan membahayakan tatanan dunia di mana-mana, termasuk di Timur Tengah dan di mana-mana sahaja China mengancam kepentingan Barat."Kita akan berakhir dalam dunia di mana kekuatan adalah hak," kata Zelenskyy. "Ia akan menjadi dunia yang sama sekali berbeza, pertembungan global."Walaupun kritiknya terhadap Vance, Zelenskyy cuba menekankan bahawa dia telah mengalami pengalaman yang berbeza dalam urusannya dengan calon ketua Republikan untuk presiden."Saya harus mengatakan bahawa tidak begitu dengan Trump. Dia dan saya bercakap melalui telefon, dan pesannya sepositif yang boleh dari sudut pandangan saya," kata Zelenskyy kepada The New Yorker, menguraikan pujian yang dikeluarkan oleh Trump seperti "Saya faham" dan "Saya akan memberi sokongan."Trump telah mendapat kritikan kerana gagal untuk memperincikan apa yang akan dilakukan oleh pentadbirannya dalam membantu Ukraine, walaupun dia telah secara lantang mengkritik jumlah bantuan yang telah diberikan Washington kepada Kyiv.Bekas presiden itu berkata bahawa jika terpilih, dia akan menamatkan perang antara Ukraine dan Rusia sebelum mengambil jawatan tertinggi pada Januari 2025, walaupun dia tidak menjelaskan bagaimana dia akan melakukan ini."Trump membuat kenyataan politik dalam kempen pilihan rayanya," kata Zelenskyy. "Perasaan saya ialah Trump tidak benar-benar tahu cara menghentikan perang, walaupun dia mungkin berfikir bahawa dia tahu caranya.""Dengan perang ini, sering kali semakin dalam anda melihatnya, semakin kurang anda faham," tambah Zelenskyy.Zelenskyy, yang berada di AS untuk menghadiri Perhimpunan Agung Pertubuhan Bangsa-Bangsa Bersatu, berkata dia akan bertemu dengan Biden untuk membentangkan "pelan kemenangan" yang bertujuan untuk menyatukan sekutu Barat lebih lanjut menentang Rusia dan mengamankan Ukraine kepada tahap yang lebih besar.Presiden Ukraine tidak memperincikan apa yang terdapat dalam pelan itu, walaupun ia dijangka termasuk seruan untuk bantuan ketenteraan tambahan dan jaminan keselamatan, walaupun ia juga boleh termasuk rancangan untuk mempercepatkan kemasukan Kyiv ke dalam EU dan perikatan lain yang seumpamanya."Ukraine yang kuat akan memaksa Putin untuk berunding. Saya yakin tentang itu," kata Zelenskyy.Terdapat kebimbangan bahawa Biden boleh menolak seruan untuk lebih banyak bantuan AS kepada Ukraine dengan pilihan raya presiden hanya lebih dari sebulan setengah lagi."Itu adalah pemikiran yang mengerikan. Ia akan bermakna bahawa Biden tidak mahu menamatkan perang dengan cara yang menafikan kemenangan kepada Rusia. Dan kita akan berakhir dengan perang yang sangat lama, keadaan yang mustahil dan meletihkan yang akan membunuh sejumlah besar orang," tambahnya.Tetapi Zelenskyy juga berkata Ukraine sudah biasa "hidup dalam Pelan B" dan dia tidak "menyalahkan" Biden atas bagaimana perang itu berlaku."Pada akhirnya, dia mengambil langkah yang berkuasa dan bersejarah ketika dia memilih untuk menyokong kami pada permulaan perang, tindakan yang mendorong rakan kongsi lain kami untuk melakukan perkara yang sama," tambahnya.Walaupun Zelenskyy juga memberi amaran bahawa keamanan hanya boleh dicapai jika Kyiv diberikan apa yang diperlukan untuk berada dalam kedudukan untuk berunding dengan Moscow dengan sewajarnya."Jika anda tidak mahu perang ini berlarutan, jika anda tidak mahu Putin menguburkan kami di bawah mayat rakyatnya, mengambil lebih banyak nyawa Ukraine dalam proses itu, kami menawarkan anda pelan untuk mengukuhkan Ukraine," katanya. "Ia bukan fantasi dan bukan fiksyen sains, dan yang penting, ia tidak memerlukan Rusia untuk bekerjasama untuk berjaya."Pelan itu menyatakan apa yang boleh dilakukan oleh rakan kongsi kita tanpa penyertaan Rusia. Jika diplomasi adalah keinginan kedua-dua pihak, maka sebelum diplomasi boleh berkesan, pelaksanaan pelan kita hanya bergantung kepada kita dan rakan kongsi kita," tambah Zelenskyy.Kempen Vance tidak membalas permintaan untuk komen daripada Axios Digital.Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Biden Akan Berucap di Perhimpunan Agung PBB Kali Terakhir Semasa Diktator dan Despot Datang ke New York berita

Biden Akan Berucap di Perhimpunan Agung PBB Kali Terakhir Semasa Diktator dan Despot Datang ke New York

(SeaPRwire) - Presiden Biden dijangka menyampaikan ucapan di pada Selasa pagi ketika pemimpin dan wakil daripada 134 negara berbondong-bondong ke Bandaraya New York untuk konvensyen tersebut. Walaupun begitu, ketua-ketua negara beberapa negara autoritarian utama yang terlibat dalam konflik antarabangsa di seluruh dunia tidak akan hadir.Walaupun Presiden Rusia Vladimir Putin, Presiden China Xi Jinping dan pemimpin Korea Utara Kim Jong Un tidak akan hadir, Presiden Iran Masoud Pezeshkianis dijangka menyampaikan ucapan pada hari Selasa walaupun mendapat tentangan antarabangsa berikutan sokongan Tehran terhadap keganasan, campur tangan dalam pilihan raya AS November dan ancaman pembunuhan terhadap ahli politik Amerika, termasuk bekas Presiden Trump.Menurut laporan pada hari Isnin, Pezeshkian memberitahu wartawan dari New York, "Kami tidak mahu berperang … kami mahu hidup dalam keamanan."Tetapi komen beliau tidak dijangka diterima begitu sahaja, dan Biden, yang akan berucap sebelum presiden Iran, akan "mengumpulkan tindakan global untuk menangani cabaran paling mendesak di dunia," kata setiausaha akhbar Rumah Putih Karine Jean-Pierre pada hari Isnin.Biden dijangka menggariskan keutamaan pentadbirannya dan visi untuk badan antarabangsa itu dalam ucapan terakhirnya kepada PBB sebagai presiden.Menurut Linda Thomas-Greenfield, Washington mempunyai tiga bidang tumpuan utama yang akan ditekankan semasa acara minggu ini, termasuk usaha berterusan untuk "menamatkan wabak perang" kerana kira-kira suku penduduk dunia tinggal di "kawasan yang terjejas konflik" di tengah-tengah perang yang semakin meningkat.AS juga merancang untuk mendorong negara anggota lain untuk meningkatkan sokongan mereka kepada pekerja bantuan kemanusiaan sambil berusaha mewujudkan sistem antarabangsa yang lebih "inklusif dan berkesan" dengan menambah dua kerusi tetap baru di Majlis Keselamatan PBB (UNSC) untuk negara-negara Afrika serta satu lagi kerusi berputar yang dikhaskan untuk Negara-negara Berkembang Kepulauan Kecil.Tetapi ketika pentadbiran Biden bergerak untuk mengubah keadaan dalam badan antarabangsa itu, sementara beberapa , seorang pakar PBB menyatakan kebimbangannya bahawa PBB sedang mengelakkan ancaman hari ini dengan mengadakan mesyuarat yang memberi tumpuan kepada kebimbangan samar hari esok."Saya berharap [ada] 'Sidang Kemuncak Masa Kini' dan bukan 'Sidang Kemuncak Masa Depan', kerana masa depan memberi kita peluang untuk menjadi samar," kata Hugh Dugan, yang bertugas sebagai delegasi AS ke Pertubuhan Bangsa-Bangsa Bersatu dan sebagai penasihat kanan kepada 11 duta besar AS ke PBB antara 1989 dan 2015, kepada Digital merujuk kepada acara "Sidang Kemuncak Masa Depan" yang diadakan pada hujung minggu."Banyak hiperbola akan didengar minggu ini," tambahnya. "Jika ia 'Sidang Kemuncak Masa Kini', itu bermakna kebertanggungjawaban sekarang, sama ada kita berkesan sekarang dan sama ada PBB cekap."Walaupun seruan Thomas-Greenfield untuk "harapan" semasa ucapannya pada hari Jumaat, terdapat rasa muram yang ketara menjelang sidang kemuncak itu kerana konflik antarabangsa yang besar berterusan tanpa pengakhiran yang jelas, termasuk perang Rusia di Ukraine, , pengambilalihan geng Haiti, dan perang saudara di Sudan dan Myanmar.Setiausaha Agung PBB Antonio Guterres memberitahu wartawan minggu lalu bahawa Sidang Kemuncak Masa Depan adalah cabaran yang diajukan kepada negara-negara tahun lepas untuk bersiap sedia dan "dilahirkan daripada kenyataan pahit: Cabaran antarabangsa bergerak lebih cepat daripada kemampuan kita untuk menyelesaikannya."Guterres menyerlahkan "perpecahan geopolitik yang tidak terkawal" dan konflik yang "tidak terkawal", perubahan iklim dan laluan ke hadapan yang tidak jelas tentang cara untuk mengatasi kecerdasan buatan, yang merupakan isu besar yang telah mengenai cara untuk membangunkan dan menggunakannya merentasi pelbagai sektor, termasuk integrasi ketenteraan."Institusi dan rangka kerja global hari ini sama sekali tidak mencukupi untuk menangani cabaran yang kompleks dan bahkan eksistensial ini," katanya. "Dan bukan sesuatu yang mengejutkan. Institusi-institusi itu dilahirkan dalam zaman dahulu kala untuk dunia dahulu kala."Kita tidak dapat mewujudkan masa depan yang sesuai untuk cucu kita dengan sistem yang dibina untuk datuk nenek kita," amarannya dengan nada yang dijangka akan berlaku sepanjang sidang kemuncak itu.Tetapi Dugan sekali lagi menunjuk kepada isu kebertanggungjawaban, dan dia mempersoalkan sama ada lebih mudah bagi pegawai tertinggi PBB untuk mendesak perubahan besar dalam PBB daripada menilai sebarang salah urus wang, birokrasi dan politik dalaman dalam PBB.Walaupun 134 negara akan menghadiri acara tahun ini, ketua dua daripada lima kerusi tetap UNSC akan tidak hadir kerana Xi dari China dan Putin dari Rusia telah menghantar delegasi sebagai ganti, satu tindakan yang semakin biasa dalam beberapa tahun kebelakangan ini.Dugan, yang bertugas di Majlis Keselamatan Negara semasa pentadbiran Trump di mana dia menangani organisasi antarabangsa, berkata amalan ini membolehkan pemimpin autoritarian mengelakkan keperluan untuk menjawab soalan-soalan sukar yang kebanyakannya berasal dari negara-negara Barat dan sekutu serantau mereka, tetapi ia juga menunjukkan bahawa mereka "tidak peduli untuk menunjukkan rasa tidak hormat."Ketika ditanya mengenai dan kesahihannya, khususnya Majlis Keselamatan PBB, yang telah menjadi sangat terpecah antara AS, Britain dan Perancis berbanding Rusia dan China selepas pencerobohan Putin ke atas Ukraine, Dugan berkata dia percaya Majlis Keselamatan PBB terus memegang kedudukan penting dalam masyarakat global."Saya sentiasa berpendapat bahawa ia memang sah," katanya. "Mudah bagi kita untuk berkata, baiklah, ia tidak dapat mencapai konsensus, atau ia tidak mencapai dan, oleh itu, berkata ia tidak sah. Saya tidak percaya itu benar."Ujian sebenar keupayaannya ialah kemampuannya untuk terus mengumpulkan orang di sekeliling meja," Dugan meneruskan. "Walaupun ketua negara tidak berada di meja itu, delegasi tahu bahawa terlalu berbahaya untuk tidak berada di meja itu."Artikel ini disediakan oleh pembekal kandungan pihak ketiga. SeaPRwire (https://www.seaprwire.com/) tidak memberi sebarang waranti atau perwakilan berkaitan dengannya. Sektor: Top Story, Berita Harian SeaPRwire menyampaikan edaran siaran akhbar secara masa nyata untuk syarikat dan institusi, mencapai lebih daripada 6,500 kedai media, 86,000 penyunting dan wartawan, dan 3.5 juta desktop profesional di seluruh 90 negara. SeaPRwire menyokong pengedaran siaran akhbar dalam bahasa Inggeris, Korea, Jepun, Arab, Cina Ringkas, Cina Tradisional, Vietnam, Thai, Indonesia, Melayu, Jerman, Rusia, Perancis, Sepanyol, Portugis dan bahasa-bahasa lain.
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Mazda to open new R&D office in Azabudai Hills in early summer 2025 JCN Newswire

Mazda to open new R&D office in Azabudai Hills in early summer 2025

TOKYO, Sept 24, 2024 - (JCN Newswire via SeaPRwire.com) - Mazda Motor Corporation will open a new R&D office in the cosmopolitan Azabudai Hills (Azabudai, Minato-ku, Tokyo) in early summer 2025, an area projected to see continuous development.Mazda has set out its 2030 VISION "to be a car-loving company that creates moving experiences through the 'joy of driving'" and aspires to an ideal where everyone connected to the Mazda brand feels mentally refreshed, physically invigorated, and optimistic about each day.As advanced technologies such as generative AI gain widespread use, it is crucial to continue innovating software technologies alongside traditional hardware to deliver vibrant, engaging experiences to our customers through their cars. The new R&D office is expected to house development facilities, particularly in software, demonstrating Mazda's goal to become a dynamic workplace of choice for software engineers. It will also function as a hub for collaborative innovation, fostering partnerships with universities, companies, and research institutions in the Tokyo metropolitan area.Based on the belief that our people are our most valuable resource, Mazda is promoting initiatives, like this new R&D office, to maximize the contributions of its personnel, including corporate culture reforms, improvements to HR systems, and the establishment of value-creation platforms.In our aspiration to create a comfortable working environment, the new R&D office will feature an open workspace and be equipped with the latest technology. Further details regarding the specific floor area and facilities will be announced in due course.Azabudai Hills, the location for Mazda's new R&D officeTrue to Mazda's "human-centered" philosophy and commitment to the pursuit of a comfortable and rewarding work environment, we endeavor to create an exemplary company where every employee feels the pride and energy to work with enthusiasm. Copyright 2024 JCN Newswire via SeaPRwire.com.
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Rozebalamin(R) for Injection 25 mg (Mecobalamin) Approved in Japan for Amyotrophic Lateral Sclerosis JCN Newswire

Rozebalamin(R) for Injection 25 mg (Mecobalamin) Approved in Japan for Amyotrophic Lateral Sclerosis

Eisai Co., Ltd. announced today that it has obtained manufacturing and marketing authorization approval for amyotrophic lateral sclerosis (ALS) treatment “Rozebalamin® for Injection 25 mg” (mecobalamin) in Japan as a treatment for slowing progression of functional impairment in amyotrophic lateral sclerosis. In May 2022, it received orphan drug designation, and a new drug application was submitted in January 2024, leading to this approval.This approval is based on the results of JETALS (The Japan Early-Stage Trial of Ultrahigh-Dose Methylcobalamin for ALS), multicenter, placebo-controlled, double-blind, randomized Phase III clinical trial in 130 patients with ALS, that was conducted as an investigator-initiated trial by a research team with Extraordinary Professor Ryuji Kaji (Principal Investigator), Tokushima University, and Professor Yuishin Izumi (Coordinating Investigator), the Department of Neurology, Tokushima University Graduate School of Biomedical Sciences, and Professor Satoshi Kuwabara (Coordinating Investigator), the Department of Neurology, Chiba University Graduate School of Medicine.In JETALS, the mecobalamin 50mg group showed a statistically significant slowing of progression compared to the placebo group in the change in total score from the end of the observation period to week 16 of the treatment period in the primary endpoint, the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) (slowing decline by approximately 43%, p=0.01).1 The adverse drug reaction incidence rates were 1.6% in the placebo group and 7.7% in the mecobalamin 50 mg group. Adverse reactions observed in the mecobalamin 50 mg group included constipation, injection site pain, fever, electrocardiogram QT prolongation and rash, each occurring in 1.5% of patients.2ALS is an intractable, progressive, neurodegenerative disease that results in severe muscle atrophy and weakness in the muscles due to motor neuron dysfunction. As the main cause of death is respiratory failure due to paralysis of the respiratory muscles, without the use of an artificial respirator, death occurs within approximately 2 to 5 years from the onset of the disease.3 The number of patients in Japan is estimated to be approximately 10,000. 3 Currently, there is no curative treatment established for ALS, and since there are only limited number of medicines approved in Japan and abroad, this is a disease with significant unmet medical needs.Eisai considers neurology a therapeutic area of focus. As a human healthcare company, Eisai is committed to further addressing the diverse needs of, and increasing the benefits of, patients and their families by providing Rozebalamin as a new treatment option for ALS patients.1. Product Outline1) Product nameRozebalamin® for Injection 25 mg2) Generic nameMecobalamin3) Indication for useSlowing progression of functional impairment in amyotrophic lateral sclerosis4) Dosage and administrationThe usual dose of mecobalamin in adults is 50 mg a day, twice a week, injected intramuscularly.About Rozebalamin (generic name: mecobalamin, development code: E0302)Mecobalamin is approved and marketed as Methycobal®, a 500 µg injection of mecobalamin indicated for the treatment of peripheral neuropathies and megaloblastic anemia caused by vitamin B12 deficiency. Methycobal is also approved as a tablet formulation (250 µg and 500 µg) as well as a fine granule formulation (0.1%) indicated for the treatment of peripheral neuropathies. While the mechanism of action of mecobalamin against amyotrophic lateral sclerosis (ALS) is not known, it has been suggested in non-clinical research that mecobalamin may have efficacy through a neuroprotective effect and regeneration of nerve axons. Since the 1990s, clinical research has been carried out on ultrahigh-dose mecobalamin in ALS by a study group on neurodegenerative disease, funded through the Ministry of Health, Labour and Welfare's Specified Disease Treatment Research Program. Short- and long-term trials of intramuscular injection of mecobalamin at 25 mg and 50 mg per day, which is respectively 50 and 100 times the approved dosage of Methycobal, suggested that ultrahigh-dose mecobalamin could have a clinical effect in ALS, and Eisai then conducted the Phase II/III clinical trial (Study 761) from 2006. Eisai submitted a new drug application for ultrahigh-dose mecobalamin as treatment for ALS in May 2015 but withdrew the application in March 2016 after the Pharmaceuticals and Medical Devices Agency (PMDA) indicated that additional clinical trials were necessary.After obtaining favorable results in the investigator-initiated Phase III trial JETALS, and following consultation with Tokushima University, Eisai submitted a new drug application for the treatment of ALS in Japan in January 2024, leading to this approval.About Japan Early-stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS)The Japan Early-stage Trial of Ultrahigh-Dose Methylcobalamin for ALS (JETALS) is an investigator-initiated study conducted as a multicenter, placebo-controlled, double-blind, randomized Phase III clinical trial to verify the efficacy and safety of high-dose methylcobalamin (mecobalamin) in patients with amyotrophic lateral sclerosis (ALS).1Mecobalamin 50 mg or placebo was administered intramuscularly twice weekly for 16 weeks to 130 ALS patients who had suffered from ALS for less than one year, were classified as “definite”, “probable”, or “probable- laboratory supported” according to the Updated Awaji Criteria, had an ALS severity rating of grade 1 or 2, had a decrease of 1 or 2 points in the total score on the Revised ALS Functional Rating Scale-Revised (ALSFRS-R) 12 weeks prior to administration, and had a forced vital capacity (%FVC) of more than 60%.2The primary endpoint was the change in ALSFRS-R total score from the end of the observation period to week 16 of the treatment period. The change was -2.7 [95% confidence interval (CI): -3.9, -1.5] in the mecobalamin50 mg group and -4.6 [95% CI: -5.8, -3.4] in the placebo group, with a difference in change of 2.0 (95% CI: 0.4, 3.5; p=0.012), verifying the superiority of mecobalamin 50 mg over placebo.2 The adverse drug reaction incidence rate was 1.6% (1/64 cases) in the placebo group and 7.7% (5/65 cases) in the mecobalamin 50 mg group. Adverse drug reactions observed in the mecobalamin 50 mg group were constipation, injection site pain, fever, electrocardiogram QT prolongation, and rash, occurring in 1.5% (1/65 cases) each.2(1) Oki R, et al. Efficacy and safety of ultrahigh-dose methylcobalamin in early-stage amyotrophic lateral sclerosis a randomized clinical trial. JAMA Neurol. 2022;79(6):575-583.(2) Information stated in the package insert.(3) Japan Intractable Diseases Information Center, Amyotrophic lateral sclerosis (ALS), Designated intractable disease (2). https://www.nanbyou.or.jp/entry/52. Last accessed: September 2024. (Japanese only)Media Inquiries:Public Relations Department, Eisai Co., Ltd.+81-(0)3-3817-5120 Copyright 2024 JCN Newswire via SeaPRwire.com.
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Valuufy CEO to present at the UN Science Summit (SSUNGA79) JCN Newswire

Valuufy CEO to present at the UN Science Summit (SSUNGA79)

KYOTO, Japan, September 24, 2024 - (JCN Newswire via SeaPRwire.com) - Valuufy, a pioneering force in sustainability assessment, announces its CEO Kyle Barnes will present at the prestigious Science Summit at the United Nations General Assembly (SSUNGA79) on September 26 as part of a larger panel session on the important role of SMEs in global sustainability efforts. This marks the third consecutive year that the Value Model has been included in this global forum.Valuufy's presentation will showcase how SMEs can become a more powerful force in global sustainability efforts. The session, "Empowering SMEs: Blockchain & AI for Sustainable Stakeholder Value", will also demonstrate how the ValuuCompass enables businesses of all sizes to measure, understand, and enhance value creation across all stakeholder groups.This is the third time the Value Model (which evolved into the ValuuCompass) has been presented at the SSUNGA, reinforcing the global relevance and potential of the ValuuCompass in addressing complex sustainability challenges, and offering a potential outline for how a post-SDGs could function."The ValuuCompass aims to become a global standard for sustainability by 2030, and this platform allows us to get important feedback at one of the world’s most important sustainability-focused events. We're excited to explore how blockchain and AI can help smaller businesses navigate the complex world of sustainability and position themselves as leaders in the post-SDG era," shares Kyle Barnes, CEO of Valuufy."We are honored to introduce the ValuuCompass as a powerful tool for driving sustainable business practices, especially for SMEs at this year’s Science Summit for the United Nations General Assembly."The ValuuCompass was developed by the Value Research Center at Doshisha University and is a practical tool that helps organizations measure their impact on seven key stakeholders: the organization itself, shareholders, employees, customers, partners, society, and the planet.“We know that a post-SDG world needs to act for people, planet, and prosperity and Valuufy speaks to this imperative. Its participation in SSUNGA79 builds on the discussions from previous years' presentations, which introduced the Value Model and explored its role in creating a sustainable post-SDG future,” acknowledges Heather Young, SSUNGA Japan Co-Chair.This year's focus on empowering SMEs with blockchain and AI technologies demonstrates Valuufy's commitment to making sustainable practices accessible and impactful for businesses of all sizes, and will include speakers across academia and business to explore how best to integrate the collective actions of SMEs to ensure global sustainability success.The virtual session is scheduled for Thursday, September 26, 2024, from 16:00 to 18:00 JST. There is no cost to attend, but registration is required: https://sched.co/1l8mcAbout ValuufyValuufy seeks to transform how the world understands and acts on sustainability. Founded in 2024, Valuufy, Inc is a registered Japanese startup in Kyoto, Japan, born of 10 years’ academic value research at Doshisha University and the Value Research Center. Led by an international team with expertise in value research, sustainability strategies, innovative technologies, business development, and ESG assessments, Valuufy provides a suite of products and services to promote value creation activities across stakeholders for businesses of all sizes. Valuufy aims to set new standards in transparent, data-driven decision-making in the realm of sustainability and value creation. For more on Valuufy's products and services and its impact on shaping the future of sustainability strategies, visit www.valuufy.com.Press and Media enquiries:news@valuufy.comFollow us:linkedin.com/company/valuufy Copyright 2024 JCN Newswire via SeaPRwire.com.
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Anticancer Agent “Tasfygo(R) Tablets 35mg” (Tasurgratinib Succinate) Approved in Japan for Biliary Tract Cancer with FGFR2 Gene Fusions or Rearrangements JCN Newswire

Anticancer Agent “Tasfygo(R) Tablets 35mg” (Tasurgratinib Succinate) Approved in Japan for Biliary Tract Cancer with FGFR2 Gene Fusions or Rearrangements

TOKYO, Sept 24, 2024 - (JCN Newswire via SeaPRwire.com) - Anticancer Agent “Tasfygo(R) Tablets 35mg” (Tasurgratinib Succinate) Approved in Japan for Biliary Tract Cancer with FGFR2 Gene Fusions or RearrangementsEisai Co., Ltd. announced today that it has obtained manufacturing and marketing approval for fibroblast growth factor receptor (FGFR) selective tyrosine kinase inhibitor “TASFYGO® Tablets 35mg” (tasurgratinib succinate) in Japan for the treatment of patients with unresectable biliary tract cancer with FGFR2 gene fusions or rearrangements that progressed after cancer chemotherapy. In Japan, it has received orphan drug designation from the Ministry of Health, Labour and Welfare (MHLW), and the marketing authorization application was submitted in December 2023.This approval is based on data such as the results of a multicenter, open-label, single-arm clinical phase II trial (Study 201) conducted by Eisai in Japan and China. Study 201 enrolled 63 patients with unresectable advanced or metastatic cholangiocarcinoma with FGFR2 gene fusions or rearrangements previously treated with gemcitabine-based combination chemotherapy. The primary endpoint of this study was objective response rate (ORR), and secondary endpoints included safety.1 This study achieved its primary endpoint and exceeded a prespecified tumor response threshold (15%) with statistical significance: ORR of patients treated with TASFYGO was 30.2% (90% confidence interval (CI): 20.7-41.0) as assessed by independent imaging review. Treatment-emergent adverse events (incidence of 25% or more) observed in this study were hyperphosphataemia (81.0%), palmar-plantar erythrodysaesthesia syndrome (44.4%), diarrhoea (36.5%), aspartate aminotransferase increase (31.7%), alanine aminotransferase increase (28.6%) and stomatitis (25.4%).The estimated number of patients in Japan with biliary tract cancer is approximately 22,0002,3 with approximately 25% of the five-year relative survival rate,2 making it an intractable cancer with the second worst prognosis following pancreatic cancer. Since drug therapy options are limited in comparison with other cancers, it is a disease with significant unmet medical needs. FGFR2 gene fusions or rearrangements are observed in approximately 14% of intrahepatic cholangiocarcinoma, which accounts for 15-30% of biliary tract cancers.4 FGFR genetic aberrations such as the gene fusions are known to be deeply involved in the proliferation, survival and migration of cancer cells as well as tumor angiogenesis and drug resistance. As these genetic aberrations in FGFRs have been observed in various other types of cancers as well as biliary tract cancer, there is growing interest in FGFRs as a promising target for cancer therapy. TASFYGO is thought to show tumor growth inhibition by selectively inhibiting FGFR1, 2 and 3, and blocking those signals.5,6 In non-clinical studies, the antitumor activity of TASFYGO was confirmed in cells expressing the FGFR2-fusion genes, which were identified by the National Cancer Center Japan (Headquarters: Tokyo) through large-scale genomic analysis of Japanese biliary tract cancer. The companion diagnostic test to detect FGFR2 gene fusions or rearrangements for the use of TASFYGO in biliary tract cancer, “AmoyDx® FGFR2 Break-apart FISH Probe Kit” by Nihon Stery, Inc. (Headquarters: Tokyo) was approved in August 2024.7Eisai aims to make continuous efforts to meet the diversified needs of and increase the benefits provided to patients with cancer, their families, and healthcare professionals, by delivering TASFYGO as a new treatment option for biliary tract cancer with FGFR2 gene fusions or rearrangements.1. Product Information1) Brand nameTASFYGO® Tablets 35mg2) Generic nameTasurgratinib succinate3) IndicationsUnresectable biliary tract cancer with FGFR2 gene fusions or rearrangements that progressed after cancer chemotherapy4) Dosage and AdministrationThe usual adult dose of tasurgratinib is 140mg orally once daily under fasting conditions. The dose may be reduced appropriately according to the condition of the patient.About “TASFYGO® Tablets 35mg” (tasurgratinib succinate, Development Code: E7090) Discovered in-house by Eisai’s Tsukuba Research Laboratories, TASFYGO is an orally available novel tyrosine kinase inhibitor that demonstrates selective inhibitory activity against fibroblast growth factor receptors (FGFR) FGFR1, FGFR2 and FGFR3. Distinct from prior known FGFR inhibitors, TASFYGO has a basic structure which lacks the dimethoxyphenyl moiety, and in a kinetic interaction analysis study, it was observed that TASFYGO demonstrates antitumor activities due to inhibition of kinase activity with a binding mode (Type V) that exhibits rapid and potent binding as well as high selectivity to FGFR. 5,6In non-clinical studies for biliary tract cancer, NIH/3T3 cells expressing FGFR2-AHCYL1, FGFR2-KCTD1, FGFR2-BICC1 or FGFR2-TXLNA as FGFR2-fusion genes, provided by the National Cancer Center Japan, were used. The antitumor activity of TASFYGO against FGFR2 gene fusion-positive cancers was confirmed in these models by evaluating its effect on anchorage-independent growth and subcutaneously transplanted tumor growth in mice.6A Phase I clinical trial is underway in Japan in patients with estrogen receptor-positive and HER2-negative breast cancer.(1) Furuse J. et al. Pivotal single-arm, phase 2 trial of tasurgratinib for patients with fibroblast growth factor receptor (FGFR)-2 gene fusion-positive cholangiocarcinoma (CCA). 2024 ASCO Gastrointestinal Cancers Symposium; Abstract No. 471. https://ascopubs.org/doi/pdf/10.1200/JCO.2024.42.3_suppl.471(2) Latest statistics, Cancer Information Service, National Cancer Center, Japan. (Japanese only)(3) The 23rd Follow-up Survey Reports for Primary Liver Cancer Cases in Japan (2014-2015), 2023. (Japanese only)(4) Arai Y. et al., Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma, Hepatology, 2014, 59, 1427-1434.(5) Miyano SW. et al., E7090, a Novel Selective Inhibitor of Fibroblast Growth Factor Receptors, Displays Potent Antitumor Activity and Prolongs Survival in Preclinical Models, Molecular Cancer Therapeutics, 2016, 15, 2630-2639.(6) Kawano S. et al., Antitumor Activity of Tasurgratinib as an Orally Available FGFR1-3 Inhibitor in Cholangiocarcinoma Models With FGFR2-fusion, Anticancer Research, 2024, 44, 2393-2406.(7) AmoyDx® FGFR2 Break-apart FISH Probe Kit Approved as Companion Diagnostic for Eisai’s Tasurgratinib in Japan. Available at: https://www.amoydiagnostics.com/about/press-releases/245 Last accessed: September 2024.Media Inquiries:Public Relations DepartmentEisai Co., Ltd.+81-(0)3-3817-5120 Copyright 2024 JCN Newswire via SeaPRwire.com.
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Autobrains Unveils Air2Road: Cutting-Edge Localization Technology for Automated Driving ACN Newswire

Autobrains Unveils Air2Road: Cutting-Edge Localization Technology for Automated Driving

MUNICH, GERMANY & TEL AVIV, ISRAEL, Sept 24, 2024 - (ACN Newswire via SeaPRwire.com) - Autobrains, a global leader in AI-powered automotive solutions, is pleased to unveil its latest innovation: Air2Road, a breakthrough localization technology developed to enhance the capabilities of Advanced Driver Assistance Systems (ADAS) and Autonomous Driving solutions. Powered by Autobrains' Liquid AI Technology, Air2Road delivers precise, real-time vehicle localization for safe and efficient navigation, even in challenging conditions such as occlusions, adverse weather, and complex urban environments.Autobrains' Air2Road Localization TechnologyFusing aerial images with ground images for highly precise and reliable localization.As the automotive industry accelerates toward fully autonomous vehicles, reliable and accurate localization is crucial for determining both vehicle position and the driving environment. Traditional localization systems, heavily reliant on Global Navigation Satellite Systems (GNSS) or crowd-sourced maps, face significant challenges such as limited coverage, high costs, and susceptibility to interference. Additionally, these systems rely on a single source of sensor-based information, leading to frequent errors and over-reliance on one type of input during driving."Air2Road is a game-changer for autonomous driving technology," said Igal Raichelgauz, CEO and Founder of Autobrains. "By providing multimodal redundancy and unmatched precision, Air2Road pushes the boundaries of what's achievable in vehicle navigation and safety, ensuring autonomous systems operate reliably under even in the most challenging conditions."Air2Road sets a new standard for vehicle localization by combining Signatures derived from two independent modalities - aerial imagery and ground-based perception - ensuring multimodal redundancy and accuracy. These Signatures are sparse binary hyperdimensional representations of both the driving environment and objects within it. This innovative approach overcomes many of the limitations inherent in traditional systems. These include:Multimodal Redundancy: By creating a joint representation of Signatures from two independent modalities (aerial images and ground-based data), Air2Road enables an unprecedented advantage of multimodal redundancy. Other existing systems use a fleet of vehicles with similar ground-based data sources, which increases repetitive mistakes and dependency on a single source of information.Full coverage: Unlike GNSS-based systems, Air2Road, with its Signature-based technology, continues to function effectively even under trees, bridges, between buildings, and in any other scenario with bad reception of the GNSS signal.Aerial Perception: Aerial images generate additional data layers-such as road markings, traffic signs, and obstacles-enabling safer and more efficient driving decisions and a redundancy to real-time perception.Scalable and Efficient: Traditional localization systems, such as crowd-sourced maps, require a fleet of vehicles to repeatedly traverse roads for data harvesting and building the map before the localization service becomes available for any vehicle. In contrast, Air2Road, enables the first vehicle on the road to achieve precise localization instantly, ensuring scalable deployment across various regions without compromising accuracy.Cost-Effective: Air2Road is compatible with affordable aerial imagery from multiple vendors, and its compressed Signatures technology enables large areas to be stored directly on the vehicle. This allows for a low-memory, low-bandwidth system, eliminating the need for constant cloud connectivity.Environment-Aware Path Planning: By leveraging real-time data on road conditions, traffic flow, and parking areas, Air2Road supports safer, more optimized navigation.Inspired by the human brain's ability to process multisensory information, Air2Road replicates mechanisms such as situational awareness and attention focus to ensure accurate decision-making. By filtering out irrelevant data and focusing on critical elements like road edges and buildings, the system significantly improves localization precision.With its data-driven approach and revolutionary dual-modality technology, Air2Road is poised to redefine the future of localization, facilitating safer and more reliable autonomous driving solutions.For more information about Autobrains and its cutting-edge Liquid AI and ADAS solutions, please visit autobrains.ai.Contact InformationSophia EichlerDirector of Marketingmedia@autobrains.ai+49 15167066494SOURCE: Autobrains Copyright 2024 ACN Newswire via SeaPRwire.com.
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